mRNA, programmed.
Therapeutics are evolving, and mRNA is playing a central role in the next generation of bioengineering applications. mRNAutilus is the engine driving our high-fitness mRNA design workflow.
From sequence to protein.
Co-optimal mRNA designs feed cleanly into ribosomal translation — every codon tuned to the application that matters.
simultaneously
learned from
to sequence
But existing methods for mRNA design still live in the past. The current state-of-the-art for mRNA design relies on lab-driven design. While off-the-shelf UTR components are usable at the start, they limit the potential of mRNA in an application. Complex interactions between the UTRs and the open reading frame of an mRNA influence the propensity of an mRNA to be translated into its corresponding protein, dictating that every application deserves its own tailor-made mRNA. This subtle change could drive past the fine line defining 'acceptable' mRNA fitness versus 'exceptional' mRNA fitness.
Moreover, every use case is different. mRNA can be optimized across many different properties — and the right balance depends entirely on the application. These properties represent an assortment of knobs, which ought to be tuned according to the task at hand. However, optimizing simultaneously across them is far easier said than done. Between the costs for reagents and time constraints, most projects have to settle for a less-than-ideal solution.
Our response is mRNAutilus, the engine driving our high-fitness mRNA design workflow. By learning from billions of mRNA sequences evolved over millennia, our platform can uniquely design an mRNA molecule precisely fit for any application.
Co-optimal across the full mRNA fitness landscape.
mRNAutilus simultaneously optimises every property that matters for your application — expression, durability, toxicity, manufacturability, and translation rate — no trade-offs.
Illustrative relative fitness scores across five mRNA design axes.